Evaluation of Impulse Oscillometry in Respiratory Airway Casts with Varying Obstruction Phenotypes, Locations, and Complexities

The use of impulse oscillometry (IOS) for lung function testing does not need patient cooperation and has gained increasing popularity among both young senior populations, as well in patients with breathing difficulties. However, studies the IOS sensitivity to regional obstructions are limited have shown mixed results. objective this study was evaluate performance an system 3D-printed models structural abnormalities at different locations severities. Lung trees two complexity levels were tested, one extending sixth generation (G6) other G12. responses varying glottal apertures, carina ridge tumors, segmental bronchial constrictions quantified G6 geometry. Both G12 casts prepared using high-resolution 3D printers. Overall, detected progressive airway considered study. resonant frequency dropped all three disease phenotypes models. R20Hz increased increase obstructions. Specifically, model apertures agreed reasonably complementary measurements TSI VelociCalc. In contrast high-resistance (R) models, R nearly independent demonstrated adequate remodeling central airways. changes R5Hz X5Hz vs. inconclusive study, possibly due rigid difference a container–syringe from human lungs.